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Image Search Results
Journal: Annals of neurology
Article Title: Intrinsic and Extrinsic Mechanisms of Thalamic Pathology in Multiple Sclerosis
doi: 10.1002/ana.25743
Figure Lengend Snippet: Representative case of a subject with grossly apparent hyperpigmented thalamic lesions on a 1 cm fixed coronal slice (A); enlarged lesion shown below. Both ovoid (B) and subependymal (C) lesions are noted using PLP immunohistochemistry for myelin; asterisk (*) denotes location of vessel. Magnetic resonance imaging (MRI) coronal images, with thalamus depicted with a white outline, (D) depict fluid-attenuated inversion recovery (FLAIR) and T1-Magnetization Prepared Rapid Acquisition of Gradient Echo (MPRAGE) sequences as well as ovoid (blue) and subependymal (Subep.; green) manually segmented lesions. The heart-shaped hyperpigmented lesion straddling the dorsomedial and ventrolateral nuclei is indicated with an arrow and an enlarged inset of the lesion is below (A). The lesion is demyelinated (B) and labeled as ovoid/perivascular (“Ovoid”) on MRI T1 MPRAGE (D). Subependymal lesions (C) were not identified on gross examination (A) and subtle on MRI (D; labeled “Subep.”). PV, perivascular; PLP, proteolipid protein.
Article Snippet: Primary antibodies included:
Techniques: Immunohistochemistry, Magnetic Resonance Imaging, Labeling
Journal: Annals of neurology
Article Title: Intrinsic and Extrinsic Mechanisms of Thalamic Pathology in Multiple Sclerosis
doi: 10.1002/ana.25743
Figure Lengend Snippet: Patterns of thalamic lesions characterized by immunohistochemistochemical staining for myelin (PLP) and activated microglia/macrophages (MHCII). Lesions top to bottom: chronic inactive (hypocellular center with asterisk*), chronic active (rim of hypercellularity; vessels labeled with “V”), active (hypercellular), and subependymal (Subep.) demyelination, areas of perivascular inflammation without demyelination (vessels labeled “>”). Scale bars are 3 mm for all images except for “PV inflammation” (600 μm). MHC, major histocompatibility complex; NAGM, normal appearing grey matter; PLP, proteolipid protein; PV, perivascular.
Article Snippet: Primary antibodies included:
Techniques: Staining, Labeling, Immunopeptidomics